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When food remains in the stomach for extended periods of time, patients may develop severe nausea, vomiting, dehydration, malnutrition, abdominal swelling, and painful digestive complications requiring hospitalization or emergency treatment

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The kinetics of HNO depend on the redox status of the cell, and reductive conditions promote the formation of this NO derivative (Arasimowicz-Jelonek et al

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(2016) Evaluation efficacy of ferrous sulfate therapy on headaches of 5-15 years old iron deficient children with migraine

These occur because the medications slow down stomach emptying and affect gut hormones